Excitation at the Synapse
نویسندگان
چکیده
منابع مشابه
Excitation Control: Balancing PSD-95 Function at the Synapse
Excitability of individual neurons dictates the overall excitation in specific brain circuits. This process is thought to be regulated by molecules that regulate synapse number, morphology and strength. Neuronal excitation is also influenced by the amounts of neurotransmitter receptors and signaling molecules retained at particular synaptic sites. Recent studies revealed a key role for PSD-95, ...
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in the presynaptic cell and of neurotransmitter receptors in the postsynaptic cell is believed to be one of the earliest steps leading to synapse formation (Sanes and Lichtman, 1999). An important role in synapse organization and stabilization is played by PSD95/Dlg/ZO-1 Eph receptor tyrosine kinases and their ligands, the (Garner et al., 2000). ephrins, have attracted considerable interest in ...
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hen John Heuser finished medical school at the height of the Vietnam War he was immediately eligible for the draft. Luckily for him, and for cell biology, he fulfilled his military service at the National Institutes of Health (NIH) in the United States Public Health Service. It was there that he brought the concept of " membrane recycling " to light. He brought to Thomas Reese's lab at the NIH ...
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Communication between neurons is mediated mainly by chemical synapses, at which neurotransmitters are released by the presynaptic neuron, diffuse across the narrow cleft, and activate receptors located on postsynaptic neurons. Synapses provide the structural and functional basis for the formation and maintenance of the complex neural networks that exist in the brain. This process is governed by...
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Editor's Note: These short reviews of a recent paper in the Journal, written exclusively by graduate students or postdoctoral fellows, are intended to mimic the journal clubs that exist in your own departments or institutions. For more information on the format and purpose of the Journal Club, please see Review of Huang et al. 5ЈTOP mRNA species contain a short 5Ј Tract rich in OligoPyrimidines...
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ژورنال
عنوان ژورنال: Cell
سال: 2000
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(00)00204-x